Many different types of crystal formations can be observed in live blood samples and vary greatly in size, shape and colour. They always appear as solid objects that are usually much larger than and WBCs. Crystals don’t have any organised internal cellular structure, and often have an irregular, jagged edge. They don’t move and don’t have any moving particles within them. 

Crystals are differentiated from each other by noting the appearance of the structure.

Crystal formation in the blood is a sclerotic process that is related to inflammation. The presence of crystalline forms is often associated with high blood pressure, plaque and atherosclerosis. There are

often WBCs attached and attracted to crystal formations in the blood, attempting to engulf the crystals.

This is a favourable sign and an indication of an active immune system.

Cholesterol crystals are trapezoidal structures of varying sizes that appear semi-opaque in brightfield and reflective in darkfield. They are typically greyish in colour in brightfield and due to the semi-opaque nature of the crystal RBCs are often visible under a part of the crystal. A typical cholesterol crystal also normally has two adjacent sides that form a sharp, well-defined edge or corner.


These trapezoidal crystals are usually associated with atherosclerotic plaque and considered significant if observed during analysis. Their elimination may be stimulated by specific natural treatment protocols, which would cause them to initially appear

in greater numbers before finally being eliminated.

To find out more about:

  • Implications
  • Associated Symptoms
  • Pleomorphic Perspective
  • Medical Perspective
  • General guidelines
  • Working with Cholesterol crystals
  • Further Investigations

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